Synthesis, Characterization and Study of Antibacterial Activity and Laser Efficacy of New Isoxazoline Derivatives

This "study involves the preparation of heterocyclic pentameric rings derived from isoxazoline compounds using chalcones as nuclei by reacting previously prepared chalcones with hydroxylamine hydrochloride using ethanol as solvent. Spectroscopic measurements confirmed the activity of the prepared compounds. Examples include infrared spectroscopy, proton nuclear magnetic resonance (NMR) and quantitative elemental analysis (C.H.N). Physical measurements such as melting point, color and product percentage were also performed. Bioavailability was evaluated using two known antibiotic resistant bacterial isolates (Gram-negative Escherichia coli (Gram-ve) and Gram-positive Staphylococcus aureus (Gram+ve) and compared with controls. The antibiotic comparison reagent (control) was amoxicillin. The stability of the prepared compounds against a helium-neon laser was tested over periods of 15-60 s by shining the laser on the compounds and then observing the color change and melting" point