Bioactive of Adiponectin in Metabolic Diseases a Review Article

The current study demonstrates  adiponectin role in pathogenesis also as a  biomarker diagnostic indicator with   metabolic syndrome and insulin resistance( IR). Adiponectin is    Lipoprotein secreted by adipocytes ,chemical structure of  protein adiponectin contains 244 amino acids four  domains ,  amino terminal peptide signal followed     species _specific ,, collagen-like The variable space region 22 Gly-X-Y repeat, globular carboxbyb_ terminal domain binds to   adiponectin receptor, which resembles complement factor C1q and a triangle-like topology for T.N.F levels  of several adipokines (including adiponectin)   leads to an increase in body weight and tends to act in a pro-inflammatory manner. On   other hand, the concentration of adiponectin decreases in obese subjects.     Adipokine works  a suppress inflammation Processes,. Clinical research articles  indicate   low concentrations of adiponectin may be involved in the increase in obesity-related diseases, including cardiovascular disease, inflammation, and insulin resistance.  current article concerned with  influence of adiponectin protein   at   insulin resistance ,metabolic syndrome in patients with type 2 diabetes and comorbid disorders associated with obesity .