Preparation and Characterization of Tetrazole Derivatives Derived from Schiff Bases and Evaluation of Biological Activity

This study included the preparation of heterogeneous pentagonal rings derived from tetrazole ring by reacting Schiff's radicals derived from 6-methyl-2-uracil and using them as nuclei in the preparation with sodium azide using tetrahydrofuran solvent. The compounds were confirmed using physical measurements such as color, melting point, and product percentage. Spectroscopic measurements, such as the infrared spectrum and nuclear magnetic resonance spectrum, were also used to determine the composition of the compound. The effectiveness of some of these compounds was also tested against two types of Gram-positive and Gram-negative bacteria using amoxicillin as an antibiotic.