Morphology of Lower Limb Muscles in Mechanical Injury

The results demonstrated significant differences in muscle tissue response depending on the type of anesthesia used. Rats subjected to general anesthesia exhibited more pronounced muscle fiber necrosis, higher levels of inflammatory cell infiltration, greater edema, and delayed regenerative processes compared to those receiving local anesthesia at both 24 and 72 hours post-injury. In contrast, local anesthesia was associated with better preservation of muscle structure, higher vascular density, and more favorable conditions for tissue regeneration. These findings suggest that the choice of anesthesia plays a critical role in the severity of muscle damage and the dynamics of inflammatory and regenerative responses following mechanical injury.