Use of Iodine As A Catalyst in The Synthesis and Characterization of Pyrrolidone and Evaluation of Its Biological Activity

In this field, several pyrrolidone compounds were created using iodine as a catalyst. The accuracy of the data was confirmed using spectroscopic methods, namely proton and carbon nuclear magnetic resonance (NMR), as well as mass spectrometry, to evaluate their analgesic properties using two contrasting methods: the hot plate test and the acetic acid spasm test. In the hot plate test, the results showed that the control group was unaffected by the analgesic, exhibiting consistent response times. Compound C10 showed a clear treatment of 20 mg/kg, with a treatment response time more than three times greater than the standard 10 mg/kg treatment. The number of spasms decreased to 6.2 ± 0.66 with the 10 mg/kg dose, while in compound C10, spasms were reduced to 10.10 ± 0.41, equivalent to half the pain. These results confirm that compound C10 is a promising candidate for future pain management.