MORPHOMETRIC CHANGES IN THE KIDNEYS UNDER THE INFLUENCE OF COMBINED INJURIES IN WHITE OUTBRED RATS

When studying morphometric changes in the kidneys of rats with combined injuries, we studied the following structural changes in the renal tissue at the microscopic level, including an assessment of the condition of the tubules, glomeruli, interstitial tissue and vessels. The obtained results of the study allowed us to identify fibrosis, destructive and inflammatory changes. The morphometric method was used to study the thickness of the capsule, the size of the tubules and glomeruli, the density of cellular elements and vascular structures, as well as a quantitative assessment of the area of damaged zones, necrotic areas and fibrosis zones using digital microscopes and image analysis software (eg, Image J).