Effect of Safflower Oil on Liver Enzyme Activity in Experimental Toxic Hepatitis

Liver enzyme activity is a key diagnostic tool for assessing hepatocellular injury and functional state of the liver. Toxic hepatitis typically leads to significant increases in ALT, AST, alkaline phosphatase, and GGT due to hepatocyte necrosis and membrane disruption. Correction of these changes is one of the most important criteria for evaluating hepatoprotective agents. Natural oils are of particular interest because they can modulate enzymatic activity through both antioxidant and anti-inflammatory mechanisms. Safflower oil, enriched with polyunsaturated fatty acids, may support normalization of hepatic enzymes. Comparative evaluation with cottonseed oil provides insights into the therapeutic superiority of natural oils.