METABOLIC MARKERS OF CHOLESTATIC SYNDROME IN INFANTS

Cholestatic syndrome (CS) in infants is a condition in which the outflow and/or flow of bile into the intestine is disrupted, leading to the accumulation of conjugated bilirubin and bile acids. Clinically, CHF is manifested by prolonged jaundice after the 14th day of life, acolic (discolored) stools, dark urine, hepatomegaly, itching, and insufficient weight gain. Diagnostic tactics include immediate laboratory confirmation of conjugated hyperbilirubinemia and a primary panel of liver tests: ALT/AST, alkaline phosphatase, GGTP, total/direct bilirubin, bile acids, albumin, PV/INR; at the same time, a general urinalysis, coprology, and a "stool color chart" for acholia screening