Clinical and Molecular Correlations Between Endothelial Dysfunction and NOS3 (C-786T) Gene Polymorphism in Preeclampsia

The identification of genetic and molecular predictors of preeclampsia is one of the most important challenges in modern obstetrics. Endothelial dysfunction represents a cornerstone in the disease pathogenesis, leading to impaired vascular reactivity, hypertension, and multi-organ hypoperfusion. The NOS3 gene polymorphisms, by modulating nitric oxide bioavailability, may play a crucial role in the severity and progression of preeclampsia. Clarifying these mechanisms can enhance our understanding of vascular homeostasis during pregnancy and open perspectives for personalized preventive strategies.