Publication Details
Abstract
The paper assesses the increasing demand for environmentally friendly health care products worldwide and focuses on green synthesis that will develop innovative drug delivery systems and reduce ecological impact. This study evaluates the design, synthesis, and characterization of a new hybrid nanopolymer system based on the application of degradable polymeric materials in the treatment of topical infections. The formulated systems are made from PVA, PLGA, and ZnO nanoparticles to improve mechanical stability and antimicrobial properties while achieving controlled and targeted delivery of diclofenac sodium. Biocompatible nanofibrous mats with improved surface area and porosity were fabricated by the electrospinning process. Thermal and morphological characterization studies confirmed the structural integrity of the polymeric matrix with enhanced thermal stability due to a ZnO nanoparticle reinforcement effect. In vitro drug release kinetic studies have been done, showing biphasic release patterns and proving the sustained therapeutic action of the drug for 72 h. In line with these data, the in vitro bioassay and anti-inflammatory studies demonstrated reduced expression of the pro-inflammatory cytokines IL-6 and TNF-α, proving an advanced therapeutic action of the novel system. The application of biodegradable polymers reduces pharmaceutical waste and supports green health care practices. Carbon footprint also decreases within the pharmaceutical