Characteristics of Hemostasis and Fetoplacental Circulation in Pregnant Women with Antiphospholipid Syndrome

Antiphospholipid syndrome (APS) leads to significant disturbances in hemostasis and fetoplacental circulation during pregnancy, increasing the risk of recurrent pregnancy loss. This study aimed to evaluate the pathogenic role of antiphospholipid antibodies, β2-glycoprotein I, and lupus anticoagulant during early gestation. Pregnant women with APS demonstrated marked hypercoagulation, endothelial dysfunction, and progressive placental ischemia. Ultrasound parameters and laboratory markers showed high diagnostic value for early detection of fetoplacental dysfunction. Preconception preparation and comprehensive monitoring proved essential in reducing pregnancy complications. The findings provide a foundation for developing improved clinical approaches to managing APS-associated pregnancies.