Publication Details
Abstract
Aim of the study:
To compare the efficacy and safety of ketamine 0.25 mg/kg versus ketamine 0.5 mg/kg in the prevention of chills in patients undergoing caesarean section.
design: a prospective, randomized, double-blind, placebo-controlled study. In AL sader teaching hospital Mesaan .Iraq, and AL zahraa teaching hospital / Alnajaf alashraf.
patients: 120 pregnant women 1 and 2 in ASA body status who underwent cesarean section during spinal anesthesia.
procedures
Measurements: Patient characteristics, anesthesia and surgical details, 1 and 5 minute Apgar scores, and study drug side effects were recorded. Heart rate, mean arterial pressure, oxygen saturation by pulse oximetry, eardrum temperature, chills, and degree of sedation were recorded before intrathecal injection and every 5 minutes thereafter. Patients were randomized into three groups: saline (Group C, n=30), intravenous (IV) ketamine 0.25 mg/kg (Group K-0.25, n=30) or intravenous ketamine 0.5 mg/kg (group K-0.5, n=30). Grade 3 or 4 tremor was treated with 25 mg intravenous meperidine and prophylaxis was considered ineffective.
Main Results: The number of patients with chills was significantly lower in the group 0.25 and in group K-0.5, compared to group C (P=0.001, P=0.001). Group C's eardrum temperatures were lower than both ketamine groups during the study. The mean sedation scores in the K-0.5 group were significantly higher than in the K-0.25 group or the C group at 10, 20, 30, and 40 minutes after spinal anesthesia.
Conclusion: Prophylactic IV ketamine 0.25 mg/kg was as effective as IV ketamine 0.5 mg/kg of prevents tremors in patients undergoing caesarean section under spinal anesthesia.