Preparation, Characterization of New 2-Oxo Pyran Derivatives by AL2O3-OK Solid Base Catalyst and Biological Activity Evaluation

This work included the synthesis of new derivatives of 2-Oxo pyran compounds from the reaction of chalcone with ethyl cyano acetate via a solid basic catalyst (prepared by the reaction of KNO3 with Al2O3 at (300-700) °C to obtain potassium oxide as a solid base catalyst)




Where the chalcone was prepared from the reaction of 5-bromoindanone with aromatic benzaldehyde substitutes, using physical methods and spectral analysis such as melting point, color, nuclear magnetic resonance spectroscopy 1H-NMR, 13C-NMR and FT-IR to ensure the accuracy and validity of the prepared compounds. The activity of the basophil was confirmed using scanning electron microscopy (SEM) and the biological activity was evaluated on two types of bacteria, Escherichia coli and Staphylococcus aureus.