Synthesis, Characterization and Evaluation of the Biological Activity of Some 1, 3-Oxazepine-4, 7-Dione Derivatives and Study of their Liquid Crystal Properties

This research included the preparation of Schiff bases from the reaction of (4, 4-sulfonyldianiline) with benzaldehyde derivatives, and then converted to 1,3-Oxazepine-4,7-dione derivatives from the reaction of Schiff bases with maleic anhydride. Using physical and spectroscopic methods (mp, color, proton nuclear magnetic resonance spectroscopy (1H-NMR, 13C-NMR and FT-IR) to confirm the compounds' structure and evaluate their biological activity on two types of bacteria, Escherichia coli and Staphylococcus aureus. Studying the liquid crystal phases and determining the nature of the transitions that occur in those phases using a polarized light microscope equipped with a heater.