Publication Details
Abstract
The aim of this study was to investigate the association of the LTC4S rs730012 C/A polymorphism with asthma susceptibility in Iraqi patients. Forty-five asthmatic patients and 35 healthy controls were genotyped for the rs730012 C/A gene polymorphism. The distribution frequencies of genotypes and alleles of the rs730012 gene were in Hardy-Weinberg equilibrium in both patients and control groups. The most common genotype in both control and asthma patients was the heterozygous genotype CA with a percentage of 80% and 57.78% respectively. The genotype CC was higher in the asthmatic group (40%) compared to the control group (11.43%). In contrast, genotype AA, the less predominant genotype, was less in the asthmatic group were less in asthmatic group (2.22%) compared control group (8.57%). The C allele was more predominant compared to the A allele with percentages of 51.43% and 68.89% for C, 48.57% and 31.11% for A in the control and patient groups respectively with significant differences (p =0.02451). The association analysis displayed that the individuals carrying the homozygous CC genotype were more likely to have a significantly increased risk of asthma with OR=5.1667 (Cl95%1.5562 to 17.1541) (p= 0.0073). The heterozygous CA and homozygous AA genotypes decrease the association with asthma OR=0.3421 (CI95%0.1236 to 0.9467) and OR=0.2424 (CI95%0.0241 to 2.4388) respectively. However, the difference between the control and asthma groups of the CA genotype was significant (p=0.0389) but not for the AA genotype (P=0.2289). These results suggested that the C allele might play a risk factor for asthma whereas the A allele might consider a protective role against asthma.