Publication Details
Journal: Central Asian Journal of Medical and Natural Science
Issue: Vol 4, No 6 (2023)
Pages: 98-116
ISSN: 2660-4159
Check on Google Scholar DOI: 10.51699/cajmns.v4i6.1988 Visit Article Page

Abstract

This search  included  synthesized  new hertocyclic derivatives from Isatin  (T) via reaction with 4-aminobenzoic acid to give (T2) ,and with SOCl2 to give compound (T1) , esterfication to give (T3), reacted with hydrazine to give (T4) compound  ,and with anhydrides to give(T5,T6) .The schiff base (T10) prepared from benzylaldehyde and (T9) perpared fram (T2) and thiocarbohydrazide .(T8) compound synthesized fram (T2) and semicarbzide by aring closer reaction in NaOH. This (T1-T10) compounds were measured biological and anticancer activity and give high good activity with (IC50=42.18,45.02 for compounds 12 and 3).

Keywords
Isatin Hydrazin Thiocarbohydrazide Anticancer activity Semicarbzide
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