Publication Details
Abstract
In this comprehensive study, we unveil key determinants of coronary heart disease (CHD). Age emerges as a pivotal factor, with older patients exhibiting a higher CHD risk due to age-related arterial stiffness. Elevated body mass index (BMI) is strongly associated with CHD, contributing to insulin resistance and reduced high-density lipoprotein (HDL) levels. Dysregulation in lipid profiles, particularly high levels of cholesterol (260.80±34.92), low-density lipoprotein (LDL) (98.06±22.00), triglycerides (192.68±38.52), and very low-density lipoprotein (VLDL) (41.74±9.77), plays a central role in atherosclerosis development. Paradoxically, CHD patients have lower HDL levels (39.06±5.18), known for their protective effects against atherosclerosis. We explore the complex mechanisms behind cardiac troponin (cTn) release in heart failure, suggesting various contributing factors such as apoptosis and cardiomyocyte injury. Additionally, while low vitamin D status may not directly correlate with coronary artery disease, it holds significance in cardiomyocyte physiology and the risk of heart failure and stroke. The study's results underscore the complex interplay of these factors in cardiovascular health, offering valuable insights that can inform future research and clinical approaches to managing and preventing CHD.