Publication Details
Abstract
Background: Lymphoma are group of diseases caused by malignant Lymphocyte that accumulate in lymph nodes and cause the characteristic clinical features of lymphadenopathy. Anaemia is a common feature in lymphoproliferative disease. Hepcidin: is a liver produced acute phase peptide whose overproduction leads to iron limited erythropoiesis. Aim of the study: To assess the level of hepcidin in newly diagnosed lymphoma patients. And correlate it with Hb, stage of disease, bulky disease, and B-symptoms. Patients and methods: Forty patients with newly diagnosed lymphoma were consequently selected from the haematology outpatient clinic at the Medical City24 of them were male and 16 were female. The level of hepcidin was investigated by ELISA technique. Results: The mean age for Lymphoma participants in this research was 43. 6±20. 2 years with range of (14-79) years. M:F ratio was 1. 5:129 patients were anaemic with Hb less than 12g /dL, 21patients had stage IV disease (52. 5%), 7 patients had stage III disease (17. 5%),12 patients had stage II disease (30%). Hepcidin level was significantly increased in lymphoma Patients than control group. There was significant inverse relationship between hepcidin with Hb level. There was significant positive relationship between hepcidin level with the presence of B-symptoms and stage of the disease. Conclusion: Hepcidin level was significantly increased in lymphoma patients compare to healthy control. It was significantly higher in lymphoma patient with anaemia than no anaemic patients. The adverse impact of elevated hepcidin is consistent with demonstration of higher level of hepcidin in patients with B symptoms and advanced stages.