Publication Details
Abstract
Relevance. Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of connective tissue with joint damage of the type of symmetrical erosive-destructive polyarthritis and a variety of extra articular manifestations. Renal pathology is found in RA with a high frequency - about 60%, according to various authors. Patients with RA may have various renal diseases: secondary renal amyloidosis, glomerulonephritis, interstitial nephritis, renal vascular vasculitis, nephrosclerosis, and in some cases, combinations thereof. Etiologically, kidney damage in patients with RA can be divided into 2 groups: firstly, nephropathy as one of the acute manifestations or complications of RA itself, for example, renal vascular vasculitis, chronic glomerulonephritis, secondary amyloidosis, and secondly, as a complication of drug therapy of RA: analgesic nephropathy (AN), medicinal glomerulonephritis. The pathogenesis of such different kidney diseases cannot be the same. Renal vascular vasculitis and glomerulonephritis have an immune nature, mainly immunocomplex; in severe cases, signs of an autoimmune process are recorded. The toxic effects of long-term NSAID intake on the enzyme systems of renal tubule epithelial cells and interstitium underlie the development of AN.