Chemical Effects on the Origin of Arterial Hypertension Disease

Arterial hypertension, a pervasive and multifactorial cardiovascular disorder, continues to pose a significant global health challenge. This paper explores the intricate interplay between chemical exposures and the onset of arterial hypertension, shedding light on the diverse mechanisms through which various environmental and endogenous chemicals may contribute to the development and exacerbation of this disease. Emphasizing the importance of understanding chemical-induced vascular alterations, the review synthesizes current knowledge on the impact of pollutants, heavy metals, pharmaceuticals, and endocrine-disrupting chemicals on blood pressure regulation. Furthermore, it delves into the molecular pathways implicated in chemical-induced vascular dysfunction, oxidative stress, inflammation, and endothelial dysfunction. A comprehensive analysis of epidemiological studies and experimental models underscores the relevance of chemical exposures as potential risk factors for arterial hypertension. Ultimately, this review provides valuable insights into the complex relationship between chemical agents and the pathogenesis of arterial hypertension, offering a foundation for future research and preventive strategies.