Preparation, Characterization, Evaluation of Biological Activity, and Study of Molecular Docking of Azetidine Derivatives

In this work, equal moles of hydrazone base derivatives and chloroacetyl chloride react to create quaternary rings of azetidine derivatives. Proton nuclear magnetic resonance spectroscopy, infrared spectroscopy, and physical and spectroscopic techniques were used to confirm the complex compositions. Furthermore, purity and melting points were established, and thin-layer chromatography (TLC) was used to track the development of the reaction. Researchers examined how several produced chemicals affected the development of two bacterial isolates: Escherichia coli, a gram-negative, and Staphylococcus aureus, a gram-positive. Using the MOE software (2009), molecular docking investigations were carried out for the compounds (AB12, AB13) against Escherichia coli. These molecules' most stable conformation (lowest energy barrier) was attained using the energy minimization procedure