Publication Details
Abstract
Asthma cause airway obstruction and are associated with chronic airway inflammation. Abnormal immune response to environmental stimuli has caused many cells of the innate and adaptive immune system to act. miRNAs play an important role in regulating key pathogenic mechanisms in allergic inflammation, including polarization of adaptive immune responses and activation of T cells. Material and Method: A case-control study and the implementation steps are divided into 3 main parts, include: Patient selection and sampling, examining the intensity of gene expression. Result: The present study show that the expression of miRNA-146a gene has been decrease significantly in asthma. Regarding the intensity of miRNA-146a gene expression in the patient and control groups, a significant difference can be observed between the two groups in terms of gene expression intensity (P-Value=0.0001). Conclusion: The results of the present study show that miR-146a gene expression has been significantly changed in asthma. In terms of the intensity of miR-146a gene expression in the patient and control groups, a significant difference is observed between the two groups (P-Value=0.0001), also the experiment and analysis of the obtained ROC curve shows that a significant change mir-146a in Asthma.