Publication Details
Abstract
Postoperative air leakage-alveolo-pleural fistula, is one of the most frequent and insidious complications in thoracic surgery and the main limiting factor in early discharge of patients from the hospital. One of the directions of the search for means to reduce the risk of developing these complications is the development of new implants and methods of their application. In this regard, at the present time, it is necessary to continue the development of new biocompatible coatings and methods of their application. The article considers an experimental evaluation of a new method for ensuring tightness of sutures in lung surgery to reduce the risk of such manifestations as aerostasis failure. The essence of the technique consists in intraparenchymatous injection of a gel substance into the area of lung tissue damage. The biological reactions of tissues and the timing of gel resorption in lung tissue have been studied. This range of research is of fundamental importance for the new techniques created, while the main task is precisely to study the safety of intraparenchymatous use of a gel substance. In this aspect, the effectiveness and duration of aerostasis were evaluated in ex vivo and in vivo experiments. The conducted studies have established that 3.3% Hemoben gel injected into the lung parenchyma at a dose of 1 ml per 1 g does not have an irritating and toxic effect, and according to spectrophotometric studies, it is completely removed from the lung tissue within 7-10 days. At the same time, the proposed technique is characterized by the effectiveness and safety of application, and the results obtained make it possible to apply this method in clinical practice.