The Role of Annexin A1, Copeptin, Cholesterol Concentration and AST activity in Serum of Primary Hypothyroidism Women Obese Patients

Thyroid hormones, plays an a major important and essential functions in metabolic processes. Hypothyroidism is caused by inadequate thyroid hormone synthesis or activity in  target tissues. Annexin A1 (AnxA1), is a key factor that have a role in the defense against inflammation and it is considered as endogenous agent that effects on the some types of steroid hormones (glucocorticoids). Copeptin is a small molecule that has a leucine-rich sequence, discovered by Holwerda et al. have a leucine repeats. It is share the precursor molecule with vasopressin - neurophysin II. The eighty women patients suffering have primary hypothyroidism women were participated, their ages ranged from 30 to 45 years. There a significant decrease (P>0.05) in T3 and T4 levels, a highly significant increase (<0.01) in TSH, AnxA1 and cholesterol, a significant increase (p<0.05) in the serum levels of Copeptin and AST activity in women patients group when compared to women control group.