Publication Details
Abstract
Miscarriage poses a significant health concern, with a substantial proportion attributed to immunological factors, particularly maternal immune responses towards the fetus. This study aimed to identify immunological biomarkers associated with unexplained recurrent abortions. Vaginal swabs and blood samples were collected from 100 women with recurrent abortions and 80 control women with previous normal pregnancies. Analysis revealed significantly higher T-helper 1 cytokine levels and lower T-helper 2 cytokine levels in women with recurrent abortions compared to controls. The imbalance in T-helper cell responses, indicated by elevated Th1:Th2 ratios and IFN-γ:IL-4 and IFN-γ:IL-10 ratios, suggests a potential mechanism underlying pregnancy loss. These findings underscore the importance of immune modulation in pregnancy outcomes and highlight the need for further research to elucidate underlying mechanisms and develop targeted interventions for optimizing maternal-fetal tolerance.