Publication Details
Abstract
This study explores the synthesis and characterization of new transition metal complexes using 1,3,4-thiadiazole-2-amino,5-thiol derivatives as novel ligands, with CrCl3.6H2O, FeCl3, and NiCl2.6H2O. Characterization was achieved through magnetic susceptibility, molar conductance, 1H NMR, IR spectroscopy, mass spectrometry, and elemental microanalysis (C.H.N.). The biological effects were evaluated on rats, focusing on hemoglobin (Hb), packed cell volume (PCV), liver enzymes, urea, and creatinine levels. Results indicated that the thiadiazole derivative increased Hb and PCV, while reducing liver enzymes, urea, and creatinine levels, suggesting no toxic effect and potential anti-inflammatory properties. Further studies are recommended to investigate potential anti-cancer, anti-bacterial, and anti-fungal activities. This research fills a knowledge gap by providing new insights into the bioactivity and structural characteristics of thiadiazole metal complexes.