Publication Details
Abstract
Infertility affects many men and women, with male infertility often resulting from azoospermia (complete absence of sperm) and oligospermia (low sperm count and motility). Genetic and endocrine factors are primary causes of infertility. This study aimed to investigate genetic causes and hormone levels in male infertility. We analyzed 423 infertile male patients at Al-Kut Hospital's IVF Center, focusing on hereditary sex hormone levels and abnormal karyotypes. Abnormal karyotype incidences in azoospermia and oligospermia were 7% and 23%, respectively. Among azoospermic patients, 62.7% exhibited (47,XXY) Klinefelter syndrome. Elevated FSH and LH levels were noted in azoospermic patients with abnormal karyotypes compared to testosterone levels in other groups. The study highlights the strong link between azoospermia and genetic chromosomal abnormalities, suggesting that hormone levels (testosterone, LH, FSH) in azoospermic patients with abnormal karyotypes are valuable for genetic studies, medical consultations, and assisted reproductive technologies.