Publication Details
Abstract
The prevalent liver condition known as Non-Alcoholic Fatty Liver Disease (NAFLD) is characterized by an abnormal buildup of fat in the liver cells. Conventional diagnostic methods are intrusive and impractical for routine screening, such as liver biopsies. The diagnostic and prognostic relevance of several biomarkers in NAFLD is examined in this study. A five-year observation period was used to track a longitudinal cohort of 500 NAFLD patients, with particular attention paid to biomarkers such as ALT, AST, CK-18, adiponectin, TNF-a, miR-122, FGF21, and GDF15. With miR-122, FGF21, and GDF15 demonstrating excellent predictive accuracy, the data showed substantial relationships between biomarker levels and disease development. Furthermore, adiponectin and ALT levels were markedly raised by lifestyle modifications. The aforementioned results bolster the efficacy of non-invasive biomarker-based diagnostics and underscore the significance of customized, non-pharmacological approaches in the handling of non-alcoholic fatty liver disease (NAFLD).