Publication Details
Abstract
CoV-19 is a novel infectious disease resulting from the SARS-CoV-2 coronavirus, which initially surfaced in Wuhan and swiftly expanded globally. Cross-species transmission of CoVs can be extremely deadly, as seen by the 2003 and more recent outbreaks of severe acute respiratory syndrome (SARS) and Middle-East respiratory disease. The globe has been threatened by the novel severe acute respiratory syndrome coronavirus 2 in a number of ways (SARS-CoV-2). Zonulin belongs to a family of proteins, the first of which was identified about a decade ago and is called pre-haptoglobin 2. Serum samples from 120 CoV-19 patients in total were gathered and apparently healthy group (n=60) with age range (20-70) years, admitted from AL-Hussien Teaching Hospital" in Al-muthana – Iraq. Zonulin levels were measured by enzyme-linked immunosorbent assay (kit. Metabolic parameters were measured by enzymatic spectrophotometer methods. The correlation coefficients between serum Zonulin levels and age, BMI, Elements and electrolytes were also evaluated. Serum Zonulin, CRP, D-dimer, and ferritin levels were substantially higher in CoV-19 patients (319.2±15.05) compared to control subjects (79.69±11.77), in CoV-19 patients (426.21±198.73) compared to control subjects (289.43±251), and in CoV-19 patients (738±20.09) compared to control subjects (130.66±9.2) (P <0.001). In COVID-19 patients, there was a significant negative correlation with iron, calcium, and sodium levels, but a positive correlation with age, CRP, D-dimer, and ferritin levels. When comparing the moderate COVID-19 patient group to the critical and severe patient group, the moderate patients' serum Zonulin levels were considerably higher. In CoV-19 patients, serum Zonulin levels were elevated, particularly in severe cases. As a result, Zonulin levels show promise in prognosticating CoV-19 severity. Throughout the trial period, Zonulin findings were consistently higher in the severe group than in the non-severe group.