Publication Details
Abstract
: Cefdinir is an antibiotic that belongs to the cephalosporin class of drugs. It is used to treat various bacterial infections such as pneumonia, acute bacterial exacerbations of chronic bronchitis, pharyngitis/tonsillitis, acute bacterial otitis media, and uncomplicated skin and skin-structure infections in both adults and children. It is available in the form of capsules and suspension and is sold under the brand name Sefarin®. The article aims to investigate changes in the physical properties of an oral Sefarin® suspension and analyzes the concentration of drug release, antimicrobial activity, and viscosity of samples after exposure to different temperatures in vitro. Three samples of oral (Sefarin®) suspension were reconstituted with distilled water and then stored under three different temperatures (at room temperature (25°C), in sunlight (45°C), and in a refrigerator (6°C)) for different periods. Three samples were analyzed after being stored in different conditions. The physical properties changed over time. Additionally, the percent concentration of a drug release decreased and there was a noted change in viscosity of the suspension and antimicrobial activity over time when stored at varying temperatures. In this study, we chose Sefarin ® suspension as an antibiotic to treat bacterial infections. We aimed to investigate the effect of different temperature conditions and storage periods on the concentration of drug release, antimicrobial activity, and viscosity of the dosage form. We observed that with an increase in temperature and time, the suspension lost a part of its activity and the dosage form viscosity decreased.