Understanding of the Immunological Tolerance Mechanisms Underlying the Maternal-Fetal: A Review Article

A unique set of communications is needed during a human pregnancy between the mother's uterus and the foetus with extra embryonic or placental membranes. One such communication is the immune system's adaptation to the developing embryo due to a variety of variables and cells. One risk factor that increases the chance of embryo rejection and infertility is the imbalance of immunological responses between the mother and foetus. Maternal immunity is therefore essential for the initiation and continuation of pregnancy. We present a thorough summary of the existing knowledge regarding immunological tolerance mechanisms underlying the maternal-fetal interface in this study.