Hemostatic Nanobiocomposite Based on the Base Cellulose Derivatives

A method has been developed for producing a composite biodegradable hemostatic agent in the form of films based on sodium H carboxymethylcellulose (Na-H-CMC), oxycellulose (OC), nanocellulose (NC) and chemically bound calcium ions. The contents of the components in the hemostatic agent, in terms of dry matter, were 55% for Na-H-CMC 30% for OC, 4% for NC and 11% for calcium chloride. Biodegradable films 100 µm thick were obtained; their hemostatic time was 34 ± 2 s. Studies were carried out to determine acute and chronic toxicity and hematological and biochemical parameters of the blood of experimental animals. Based on these research results, the possibility of using hemostatic compositions in practical medicine has been established.