Publication Details
Abstract
Diabetes represent a chronic disorder that involve the decline in the levels of insulin produced by the pancreas due to many genetic and environmental factors. The disease involves the elevation of blood sugar in the circulation which may lead to vascular, neurological, ocular and renal complications. In addition, diabetic patients tend to develop ulceration due to wound infection swiftly in the lower limbs due to the reduce in the neurological sensation as well as to elevated sugar circulation which may greatly provoke wound infection and diabetic foot ulcerations. The current study aimed at isolation of the common causes of bacterial infection associated with diabetic foot ulcer, The present study was conducted in Salah Aldeen province during the period from 1st of November 2023 to 15th of May 2024 and included 150 patients with diabetic foot infection who attended Salah-Alden Hospitals: (Tikrit Teaching Hospital, Balad General Hospital and private surgery clinics). Swabs and whole blood from patients with diabetic foot ulcer were taken and submitted to routine culture and identification of the causative bacterial infection followed by biochemical identification and antibiotics susceptibility test for the isolated microbe. The current data revealed that most of the patients with diabetic foot ulcer were males 59.33% while females represented 40.67% with mean age 48 years for males and 53 years for females. Most of the patients with diabetic foot ulcer were residing urban areas 80.67% while the remaining 19.33% were living in rural areas. On the other hand, 18% of diabetic patients with foot ulceration were complaining of hypertension with majority having no other associated diseases 67.33%. Regarding bacterial isolates from diabetic foot ulceration, out of 150 clinical swabs only 47.33% were positive for bacterial isolates with predominant bacterial species species being Pseudomonas aeruginosa 38.03% followed by Escherichia coli 22.53%, Klebsiella pneumonia 19.71%, Staphylococcus aureus 11.26% and Streptococcus pyogenes 8.45%. Antibiotics susceptibility test depicted that all isolates of P. aeruginosa 100% were resistant amoxicillin, ciprofloxacin and levofloxacin, while most of them were susceptible to imipenem 91%. whereas the vast isolates were resistant to amoxicillin group. Similarly, E. coli showed 93.7% resistance to amoxicillin group while 100% sensitivity to ciprofloxacin and levofloxacin antibiotics. Whereas, 92.9% of K. pneumonia isolates were resistant to amoxicillin and azithromycin and 100% sensitive to imipenem. In the same way, 50% of S. aureus isolates were resistant to ceftazidime and 100% susceptible to imipenem. As for S. pyogenes 100% of the isolates were resistant to amoxicillin while 100% sensitive to cefixime, cefotaxime, amikacin, gentamycin and imipenem.