Synthesis of Aromatic Amides and Isoquinolines Based on Homoveratrilamine

This paper outlines the synthesis of aromatic amides and isoquinoline derivatives derived from homoveratrylamine. Condensation reactions of homoveratrylamine with cinnamic and mandelic acids gave the corresponding amides in high yields. The cyclization of these amides via the Bischler-Napieralski method facilitated the synthesis of 3,4-dihydro- and tetrahydroisoquinoline derivatives. The synthesized compounds were confirmed through IR and NMR spectroscopy, as well as mass spectrometry. The results highlight the potential of these methods for synthesizing biologically active compounds based on homoveratrylamine.