In Vitro Evaluation Of Curcumin and Its Analogues (1-6) Against The MDA MB-231 Breast Cancer Cell Lines

Our previous work included the synthesis and identification of curcumin and its analogues (1-6). This study involved in vitro evaluation of curcumin and its analogues (1-6) as anti-breast cancer against MDA-MB 231cell line. Curcumin and all analogues (1-6) were assayed in vitro as anti-proliferation against the MDA-MB-231 breast cancer cell line by using the Micro-Culture Tetrazolium (MTT) method. Compound 6 (IC50 99.36 and SI 2.5) exhibited strong cytotoxic activity and selectivity than curcumin and compounds (1-5). This makes it a more promising selective agent for treating triple-negative breast cancer cell lines (TNBC) than other compounds 1–5