Secondary Hyperparathyroidism in Chronic Kidney Disease: Mechanism of Development

Secondary hyperparathyroidism (SHPT) is a condition that occurs in response to chronic hypocalcemia (low blood calcium levels) and is linked to a higher release of parathyroid hormone (PTH) by the parathyroid glands. This disease is most often a compensatory reaction of the body to calcium deficiency caused by various pathologies, especially chronic kidney disease or impaired calcium metabolism. Methods. This review article compiles existing knowledge on SHPT in CKD. The authors conducted a literature search to identify relevant studies published in peer-reviewed journals. The search strategy focused on keywords such as "secondary hyperparathyroidism," "chronic kidney disease," "calcium-phosphorus metabolism," "renal osteodystrophy," and "treatment." The retrieved articles were critically appraised to ensure their scientific merit and relevance to the topic (references to be added).