Synthesis, Characterization, and DFT cucalutions, Biological Study of Five-membered Cyclic Containing the sulfur and nitrogen

Thiazolidinediones have biological activity in pharmaceutical industry. The presence of N-3 and C-5 positions in the TZD core scaffold makes it a versatile and flexible piece that exhibits its biological activities. Therefore, two thiazolidinedione derivatives were prepared and their antimicrobial activity was studied. The antibacterial activity was measured and the computational study of the synthesized derivatives was performed using Gaussian program to calculate some important thermodynamic parameters.