Quorum Sensing Between Bacterial Communication and Neutralization to Reduce Bacterial Birulence

One of the important means by which bacteria communicate is the quorum sensing(QS) mechanism, which represents the essential point in starting their journey towards controlling the environment in which they exist through the formation of biofilms, the production of virulence factors, the production of internal and external enzymes, movement, reproduction, and spore formation. Therefore, this review sheds light on how bacterial QS occurs, forming genetic coding and the formation of the regulatory and receptor protein molecules responsible for this and their mechanism of action, to develop our strategy in our battle against mutations and resistance that occur in pathogenic bacteria as a result of the use of synthetic antibiotics and the search for natural chemical compounds extracted from plants that are effective in suppressing bacterial QS without affecting their growth, thus reducing the risk of developing resistance later, as well as getting rid of the toxicity of some drugs used in treatment.