Publication Details
Abstract
This study was intended to look at the relationship between Hematological parameters and IL-6 in men with rheumatoid arthritis in Thi Qar province/Iraq, as well as to study the effect of age, body mass index and blood groups on blood parameters. The study included 100 men, 60 of whom were RA patients and 40 healthy men as a group in control. Their ages were in the range of 45-75 years. Blood samples were used to examine ABO blood groups and complete blood count (CBC), while serum was used to measure IL-6. The samples were divided into two groups according to age group, three groups according to BMI and eight groups according to blood groups.
According to the findings, IL-6 was considerably elevated (P<0.05) in RA patients compared to the control group. In contrast, the Hematological parameters examination indicated that the total WBC was greatly raised (P<0.05) in patients, while differential count of WBC was significantly increased in neutrophils and eosinophils, while the lymphocytes were dramatically reduced (P<0.05) in patients with RA as opposed to the control group .On other hand, the red blood cell count indicated that RBC, HGB, HCT and HGB, MCV, MCH, MCHC and HGB/HCT were substantially lower in patients (P<0.05). In contrast, platelet parameters PLT, PDW and PCT were much higher (P<0.05) in patients, except for MPV, which was significantly decreased in RA patients compared to the control group.When comparing the Hematological parameters of RA patients according to age group, MPV and PDW were considerably higher (P<0.05) in the second category of age GII (60-75) years as opposed to the first age category GI (45-60) years. On the other hand, the comparison between patients according to BMI indicated that the same two parameters above were significantly increased (P<0.05) in the third group GIII (Class I obesity) compared to the first group GI (Normal weight). In contrast, the comparison between RA patients according to blood groups showed no significant differences (P>0.05) in all Hematological parameters. Blood group O recorded the highest incidence of RA while group AB recorded the lowest incidence.
The results of the correlation analysis indicated a significant positive correlation between IL-6 and each of Neu, PLT, PDW, PCT and PLT/Lym ratio while IL-6 recorded a significant negative correlation with HGB, HCT, MCV, MCHC and HGB/HCT ratio.