Publication Details
Abstract
Aim of the study: Hepatitis C virus (HCV) exhibits significant genetic diversity, influencing disease progression and treatment outcomes. This study aimed to determine the prevalence of HCV genotypes and their association with viral load and liver function in patients from Diwaniya City, Iraq. Methods: A total of 96 HCV-positive patients were recruited from private clinics in Diwaniya City. Blood samples were collected for viral load and genotyping quantification using real-time PCR. Liver function tests, including alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST) and bilirubin levels were assessed using an automated system. Results: Genotype 1a was the most prevalent (64.6%), followed by 1b (25%) and 4a (10.4%). A higher viral load was observed in males, although this difference was not statistically significant. A significant variation in viral load was found among different genotypes. Correlation analysis revealed a non-significant positive association between viral load and Liver function tests. Conclusion: Genotype 1a is the predominant HCV genotype in Diwaniya City. While viral load may influence liver function, further investigation is warranted to confirm this observation. These findings contribute to a better understanding of HCV epidemiology and clinical management in the region