Publication Details
Abstract
Triazole-based compounds are widely studied due to their diverse biological properties, including antimicrobial and antioxidant activities. Schiff base derivatives of triazoles have garnered attention for their potential coordination with transition metals, enhancing their pharmacological efficacy. While several triazole-based ligands have been synthesized, their structural elucidation, biological evaluation, and coordination with metal ions such as Co(II) and Cu(II) require further exploration to establish their full therapeutic potential. Knowledge Gap: Limited studies provide a detailed correlation between the spectroscopic characteristics, antioxidant capacity, and antibacterial effects of newly synthesized triazole Schiff bases and their transition metal complexes. This study aims to synthesize a novel Schiff base derived from 4H-1,2,4-triazole-3,5-diamine and 3-hydroxybenzaldehyde, characterize its structure using various spectroscopic methods, and evaluate its antioxidant and antibacterial activities, both as a free ligand and in complexation with Co(II) and Cu(II) ions. Structural characterization confirmed the formation of a Schiff base with successful coordination to metal ions in a 1:1 stoichiometry. The ligand demonstrated moderate antioxidant activity, with lower DPPH scavenging efficiency than ascorbic acid. Antibacterial testing revealed moderate inhibitory effects against Klebsiella and E. coli, with enhanced activity in the metal complexes. This study introduces a novel triazole-derived Schiff base and its Co(II) and Cu(II) complexes, supported by comprehensive spectroscopic and biological analyses. The results suggest that metal complexation can improve the biological activity of Schiff base ligands, indicating potential applications in the development of new antimicrobial and antioxidant agents.