Publication Details
Abstract
A new spectrophotometric method was developed for the determination of trifluoperazine in aqueous media using the oxidative reaction with the Schiff base reagent (1,3,5-triazin-2,4,6-tril)tris(azanilidene)tris(methanedilidene). This reaction was generated by a 3–5-hour condensation between the aldehyde and an aromatic amine in the presence of glacial acetic acid, resulting in a light yellow precipitate with a molecular weight of 435 g/mol and a chemical formula of C24H21N9. Conjugation occurred at pH 1.28 in the presence of the oxidizing agent potassium iodate, producing a water-soluble product with a maximum absorbance at 548 nm. The product exhibited a stability period of over 70 minutes, sufficient for several measurements, and the Beer's law limits were between 70 and 10 μg/ml of trifluoperazine. The molar absorptivity was 3651.2 L/mol/cm, and the Sandell significance level was 0.131 μg/cm. The method was effective and convenient for testing, with a specificity of 100.49%, a relative error of 1.26%, and a detection limit of 0.208 mg/L. The method was effective in the determination of trifluoperazine in tablet form in pharmaceutical preparations.