Publication Details
Abstract
Despite the fact that bladder cancer is a major public health problem in Iraq, the genetic elements that contribute to its development are still not fully understood. Through the use of a case-control approach, the purpose of this investigation is to determine whether or not the IL-6 rs1800795 (-174 G/C) polymorphism is associated with an increased risk of bladder cancer in the Iraqi population. Techniques. There were a total of 148 individuals in the research, including 78 cases and 70 controls. The participants were separated into two groups. Patients who had previously been diagnosed with bladder cancer by histological examination made up the case group. In cases, the GC genotype and the G allele were found to be significantly more prevalent than in controls (odds ratio = 2.22, p = 0.004). On the other hand, the GC and C alleles were found to be considerably more prevalent in cases. The outcomes. At the case group level, there were no statistically significant differences between the two groups in terms of the probability of developing bladder cancer (p 0.05). There was a statistically significant difference in the frequency of the GG genotype between the patients and the controls in the control group (P = $0.04). A further finding was that there was no statistically significant difference in the CC genotype between the patients and the controls (p = 0.001). I will conclude. Taking into consideration these findings, it appears that there may be a connection between the gastrointestinal genotype of the miR-146a gene and an elevated risk of lung cancer in Iraq. Given that both the miR146a SNP Rs2910164 and the miR 155 SNP rS767649 are risk factors for non-small cell lung cancer, it is important to emphasize the significance that genetic variables play in the genesis of lung cancer.