Publication Details
Abstract
Subsequent to lung cancer, laryngeal carcinoma is considered the second most common carcinoma within the aerodigestive region, representing about 20% of all H&N carcinomas. Laryngeal carcinoma is regarded as the most prevalent head and neck cancer within the Middle Euphrates regions. Recently, HR-HPV infection has been recognized as a potentially contributing factor in promoting LSCC progression. The co-expression of p16 and Ki67, the proliferation index, is considered a characteristic marker of HPV-driven cancers. The cross-sectional study involved 44 laryngeal lesions-benign, premalignant, and malignant-preserved as FFPE blocks that were classified in two main group: A) 21 sample with LSCC and B) 23 samples with benign/premalignant laryngeal lesions. Immunohistochemical analysis for p16 and Ki67, respectively. Statistical associations were evaluated using fisher’s exact and Chi square tests. P-value less than 0.05 was regarded as statistically significant. Significant correlation observed between p16 positivity and age, sex, lesion site, diagnosis, and Ki67. P16 immunohistochemical analysis is insufficient as a conclusive biomarker of HPV-driven laryngeal lesions.