Publication Details
Abstract
Polycystic Ovary Syndrome (PCOS) is a heterogeneous endocrine disorder with diverse clinical manifestations, including menstrual irregularity. While its hormonal and metabolic aspects are well-studied, the combined effects of endogenous protective proteins like Kallistatin and environmental endocrine disruptors such as Zearalenone (ZEN) on menstrual regularity remain poorly understood. A cross-sectional study was conducted on 98 women diagnosed with PCOS using the Rotterdam criteria. Participants were classified into regular and irregular menstrual cycle groups based on clinical history. Serum levels of reproductive hormones, metabolic indices, Kallistatin, and ZEN were measured and compared between the groups. A p-value <0.05 was considered statistically significant. Women with irregular menstrual cycles exhibited more severe hormonal and metabolic disturbances. They had higher median testosterone (61 vs. 45 ng/dL) and lower SHBG levels (29 vs. 43 nmol/L). Metabolic indices also showed marked differences, with higher Visceral Adiposity Index (VAI: 4.2 vs. 2.4) and Lipid Accumulation Product (LAP: 119 vs. 94) in the irregular group. Notably, this group demonstrated significantly lower median Kallistatin levels (19 vs. 111 ng/mL) and higher ZEN levels (6.0 vs. 4.9 ng/L) compared to the regular-cycle group. The findings support the hypothesis that lower Kallistatin and elevated ZEN levels contribute to reproductive and metabolic dysfunction in PCOS.