Immune-Mediated Alterations of Thyroid Autoantibodies and Hormone Levels in Pediatric Outpatients Following COVID-19 Infection with Autoimmune Thyroid Disease

The COVID-19 pandemic has systemic effects other than respiratory diseases with major impact on endocrine system. Recent investigations have demonstrated an association of thyroid dysfunction with COVID-19 in adults as well as children. It aims to explore the effect of SARS-CoV-2 infection on thyroid function (TSH, T3, T4) and thyroid autoantibodies (anti-TPO, anti-TG) in pediatric Outpatient with previous diagnosis of AITD. All patients enrolled in the study were Outpatient with COVID-19 and managing symptoms or infection .By analyzing pre-and post-COVID-19 infection profiles in 30 patients who were < 7 years old, we detect significant changes in biochemical and immunological markers, which suggest the hypothesis of COVID-19 as a trigger or exacerbating condition for pediatric thyroid dysfunction