Use of Solid Basic Catalysts in the Preparation of Cyclohexenone Derivatives and Evaluation of Their Bacterial Activity

Solid basic catalysts prepared from the reaction of potassium nitrate with alumina were used to synthesize hexagonal rings derived from cyclohexene by reacting the prepared chalcones with ethyl acetoacetate. Using the catalysts as a catalyst, cyclohexene derivatives were prepared. Biological activity was evaluated using two types of bacterial isolates known for their resistance to antibiotics, Gram-negative (Gram -ve) and Gram-positive (Gram +ve). In addition to determining the melting point and purity, physical and spectroscopic methods such as infrared spectroscopy, proton spectroscopy and carbon nuclear magnetic resonance (1H, 13C-NMR) were used to confirm the correct structure of the prepared compounds, and follow-up analysis was carried out by thin layer chromatography (TLC).