Publication Details
Abstract
This study describes the environmentally friendly synthesis of novel imidazole derivatives by the use of both conventional and microwave techniques to react Schiff bases with histidine in ethanol. Despite their importance in medicinal chemistry, imidazole molecules are still difficult to synthesize efficiently. The research included the preparation of new imidazole derivatives by reacting prepared Schiff bases with the amino acid histidine in the presence of ethanol as a solvent. The reaction was carried out using conventional and microwave methods, and the progress of the reaction was monitored and described by determining the melting point and purity. The Rf values were determined using thin-layer chromatography (T.L.C.), infrared spectroscopy (FT-IR), proton nuclear magnetic resonance (1H-NMR), and quantitative elemental analysis (C.H.N.). The biological activity of the synthesised compounds was evaluated by examining their effect on the growth of four antibiotic-resistant bacterial isolates: Gram-negative (Escherichia) and Gram-positive (Staphylococcus aureus). The antibiotic Amoxicillin was used as a control sample. The prepared compounds showed good inhibitory activity against the tested bacteria. Furthermore, the laser activity of the synthesized composites was measured using a helium-neon laser (visible laser). The composites were exposed to radiation for four different time periods (15, 30, 45, 60) seconds, and their physical properties were re-examined to observe any changes caused by the laser exposure.