Publication Details
Abstract
Background: Type 1 diabetes mellitus (T1DM) and celiac disease (CD) are the most common autoimmune diseases in children and adolescents. These conditions often co-occur in the same patient, which may be due to both diseases sharing the same genetic background. This study aimed to assess the serum levels of deaminated gliadin peptide antibodies in diabetic pediatric populations in Wasit Province, Iraq.
Methods: This study recruited 100 T1DM patients and 60 healthy individuals, both sexes, under the age of 16 years. Five ml of blood was collected from each participant to determine the level of DGP-IgA and DGP-IgG using the ELISA technique. Fasting blood sugar (FBS), random blood sugar (RBS), and glycated hemoglobin (HbA1C) were also measured.
Results: The study found that there was a significant difference in the mean levels of DGP-IgA and DGP-IgG between patients and controls, with patients having a higher mean value of DGP-IgA than controls (14.58±50.83 versus 1.82±1.36). The same was shown in DGP-IgG, where the patients had a mean of 9.39±42.18 compared to 1.87±1.64 for controls.
Conclusion: The study reveals a significant difference in anti-DGP autoantibodies between T1DM patients when comparing them with healthy controls, putting them at high risk for developing CD.