Publication Details
Abstract
Oxidative stress is a feature of hyperglycemia that results in diabetes mellitus. Propolis is a natural product which possesses a large range of biological properties as well as possesses hypoglycemic activity and oxidative stress modulation properties. We attempted in this study, to examine the anti-hyperglycemic and antioxidant activities of propolis as an add-on therapy to metformin and sitagliptin in diabetic rats. Alloxan (150 mg/kg, IP) was used to induce diabetes. It was divided into seven groups (n=6) of male albino rats Groups A (non diabetics) and Group B (diabetics) groups were divided also on the of the distilled water. Metformin: 100 mg/kg, propolis: 100 mg/kg, sitagliptin: 50 mg/kg, metformin + sitagliptin, propolis + metformin + sitagliptin were the groups C, D, E, F, and G in diabetic rats respectively. Three weeks after alloxan injection fasting blood glucose levels as well as serum MDA levels were significantly elevated, serum TAS levels were markedly decreased, and insulin resistance was significantly enhanced relative to the control non diabetic group. Conversely, oral administration of propolis in diabetic rats daily orally for 5 wks improved fasting blood sugar, serum insulin levels and HOMA-IR. TAS levels increased while the serum MDA levels decreased. Statistically, this study had findings of P<0.05. From the discussion, it is concluded that propolis has hypoglycemic and antioxidant activities capable of ameliorating oxidative stress and contributing to delaying the diabetic complications.